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1

A strategy for preclinical formulation development using GastroPlus™ as pharmacokinetic simulation tool and a statistical screening design applied to a dog study

Martin Kuentz, Sonja Nick, Neil Parrott, Dieter Röthlisberger

Journal:

European Journal of Pharmaceutical Sciences

Year:

2006

Language:

english

File:

PDF, 425 KB

english, 2006

2

Discovery of Balovaptan, a Vasopressin 1a Receptor Antagonist for the Treatment of Autism Spectrum Disorder

Schnider, Patrick, Bissantz, Caterina, Bruns, Andreas, Dolente, Cosimo, Goetschi, Erwin, Jakob-Roetne, Roland, Künnecke, Basil, Mueggler, Thomas, Muster, Wolfgang, Parrott, Neil, Pinard, Emmanuel, Rat

Journal:

Journal of Medicinal Chemistry

Year:

2020

Language:

english

File:

PDF, 3.39 MB

english, 2020

3

Best Practices in the Development and Validation of Physiologically Based Biopharmaceutics Modeling. A Workshop Summary Report.

Parrott, Neil, Suarez-Sharp, Sandra, Kesisoglou, Filippos, Pathak, Shriram M., Good, David, Wagner, Christian, Dallmann, AndrÃ©, Mullin, James, Patel, Nikunjkumar, Riedmaier, Arian Emami, Mitra, Amita

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 37 KB

2020

4

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

Parrott, Neil, Lave, Thierry

Journal:

Molecular Pharmaceutics

Year:

2008

Language:

english

File:

PDF, 1.94 MB

english, 2008

5

Application of PBPK modeling to predict human intestinal metabolism of CYP3A substrates – An evaluation and case study using GastroPlus™

Aki T. Heikkinen, Guillaume Baneyx, Antonello Caruso, Neil Parrott

Journal:

European Journal of Pharmaceutical Sciences

Year:

2012

Language:

english

File:

PDF, 648 KB

english, 2012

6

A Novel Strategy for Physiologically Based Predictions of Human Pharmacokinetics

Dr Hannah M. Jones, Neil Parrott, Karin Jorga, Thierry Lavé

Journal:

Clinical Pharmacokinetics

Year:

2006

Language:

english

File:

PDF, 388 KB

english, 2006

7

In Vitro to in Vivo Extrapolation and Physiologically Based Modeling of Cytochrome P450 Mediated Metabolism in Beagle Dog Gut Wall and Liver

Heikkinen, Aki T., Fowler, Stephen, Gray, Lynn, Li, Jia, Peng, Ying, Yadava, Preeti, Railkar, Aruna, Parrott, Neil

Journal:

Molecular Pharmaceutics

Year:

2013

Language:

english

File:

PDF, 1.43 MB

english, 2013

8

Preclinical Reproductive and Developmental Toxicity Profile of a Glycine Transporter Type 1 (Glyt1) Inhibitor

Barrow, Paul, Parrott, Neil, Alberati, Daniela, Paehler, Axel, Koerner, Annette

Journal:

Birth Defects Research Part B: Developmental and Reproductive Toxicology

Year:

2016

Language:

english

File:

PDF, 341 KB

english, 2016

9

The Ontogeny of UDP-glucuronosyltransferase Enzymes, Recommendations for Future Profiling Studies and Application Through Physiologically Based Pharmacokinetic Modelling

Badée, Justine, Fowler, Stephen, de Wildt, Saskia N., Collier, Abby C., Schmidt, Stephan, Parrott, Neil

Journal:

Clinical Pharmacokinetics

Year:

2018

Language:

english

File:

PDF, 961 KB

english, 2018

10

Physiologically Based Pharmacokinetic Modelling for First-In-Human Predictions: An Updated Model Building Strategy Illustrated with Challenging Industry Case Studies

Miller, Neil A., Reddy, Micaela B., Heikkinen, Aki T., Lukacova, Viera, Parrott, Neil

Journal:

Clinical Pharmacokinetics

Year:

2019

Language:

english

File:

PDF, 3.04 MB

english, 2019

11

Simulating the Impact of Elevated Levels of Interleukin-6 on the Pharmacokinetics of Various CYP450 Substrates in Patients with Neuromyelitis Optica or Neuromyelitis Optica Spectrum Disorders in Different Ethnic Populations

Machavaram, Krishna K., Endo-Tsukude, Chihiro, Terao, Kimio, Gill, Katherine L., Hatley, Oliver J., Gardner, Iain, Parrott, Neil, Ducray, Patricia Sanwald

Journal:

The AAPS Journal

Year:

2019

Language:

english

File:

PDF, 2.40 MB

english, 2019

12

Impact of Intracellular Concentrations on Metabolic Drug-Drug Interaction Studies

Treyer, Andrea, Ullah, Mohammed, Parrott, Neil, Molitor, Birgit, Fowler, Stephen, Artursson, Per

Journal:

The AAPS Journal

Year:

2019

Language:

english

File:

PDF, 1.20 MB

english, 2019

13

Prediction of pH-Dependent Drug-Drug Interactions for Basic Drugs using Physiologically based Biopharmaceutics Modeling: Industry Case Studies

Mitra, Amitava, Parrott, Neil, Miller, Neil, Lloyd, Richard, Tistaert, Christophe, Heimbach, Tycho, Ji, Yan, Kesisoglou, Filippos

Journal:

Journal of Pharmaceutical Sciences

Year:

2019

Language:

english

File:

PDF, 5.61 MB

english, 2019

14

Physiologically Based Absorption Modelling to Explore the Impact of Food and Gastric pH Changes on the Pharmacokinetics of Entrectinib

Parrott, Neil, Stillhart, Cordula, Lindenberg, Marc, Wagner, Bjoern, Kowalski, Karey, Guerini, Elena, Djebli, Nassim, Meneses-Lorente, Georgina

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 1.69 MB

2020

15

In Vitro Biopredictive Methods: A Workshop Summary Report

Pepin, Xavier JH., Dressman, Jennifer, Parrott, Neil, Delvadia, Poonam, Mitra, Amitava, Zhang, Xinyuan, Babiskin, Andrew, Kolhatkar, Vidula, Seo, Paul, Taylor, Lynne S., SjÃ¶gren, Erik, Butler, James

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 1.70 MB

2020

16

Applications of Physiologically Based Biopharmaceutics Modeling (PBBM) to support Drug Product Quality: A Workshop Summary Report

Mitra, Amitava, Suarez-Sharp, Sandra, Pepin, Xavier JH., Flanagan, Talia, Zhao, Yang, Kotzagiorgis, Evangelos, Parrott, Neil, Sharan, Satish, Tistaert, Christophe, Heimbach, Tycho, Zolnik, Banu, SjÃ¶g

Journal:

Journal of Pharmaceutical Sciences

Year:

2020

File:

PDF, 8.13 MB

2020

17

Correction to: In Vitro to In Vivo Extrapolation of Metabolic Clearance for UGT Substrates Using Short-Term Suspension and Long-Term Co-cultured Human Hepatocytes

Docci, Luca, Klammers, Florian, Ekiciler, Aynur, Molitor, Birgit, Umehara, Kenichi, Walter, Isabelle, KrÃ¤henbÃ¼hl, Stephan, Parrott, Neil, Fowler, Stephen

Journal:

The AAPS Journal

Year:

2020

File:

PDF, 159 KB

2020

18

Two distinct phenotypes caused by two different missense mutations in the same codon of the VHL gene

Bradley, John F., Collins, Debra L., Schimke, R. Neil, Parrott, Heather N., Rothberg, Paul G.

Journal:

American Journal of Medical Genetics

Year:

1999

Language:

english

File:

PDF, 248 KB

english, 1999

19

A fast virtual screening filter for cytochrome P450 3A4 inhibition liability of compound libraries

Jochen Zuegge, Uli Fechner, Olivier Roche, Neil J. Parrott, Ola Engkvist, Gisbert Schneider

Journal:

Molecular Informatics

Year:

2002

Language:

english

File:

PDF, 139 KB

english, 2002

20

An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery

Neil Parrott, Nicolas Paquereau, Philippe Coassolo, Thierry Lavé

Journal:

Journal of Pharmaceutical Sciences

Year:

2005

Language:

english

File:

PDF, 494 KB

english, 2005

21

Successful renal transplantation in children in the presence of thrombosis of the inferior vena cava

Mohan Shenoy, Ravi Pararajasingam, Neville B. Wright, Malcolm A. Lewis, Neil Parrott, Hany Riad, Nicholas J. A. Webb

Journal:

Pediatric Nephrology

Year:

2008

Language:

english

File:

PDF, 182 KB

english, 2008

22

Successful renal transplant during the first trimester of pregnancy

Louise C. Kenny, Philip N. Baker, Michael Venning, Neil Parrott

Journal:

Transplant International

Year:

2007

Language:

english

File:

PDF, 421 KB

english, 2007

23

Native nephrectomy for autosomal dominant polycystic kidney disease: before or after kidney transplantation?

Matthew A. Kirkman, David van Dellen, Sanjay Mehra, Babatunde A. Campbell, Afshin Tavakoli, Ravi Pararajasingam, Neil R. Parrott, Hany N. Riad, Lorna McWilliam, Titus Augustine

Journal:

BJU International

Year:

2011

Language:

english

File:

PDF, 250 KB

english, 2011

24

Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

Neil Parrott, Hannah Jones, Nicolas Paquereau, Thierry Lavé

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2005

Language:

english

File:

PDF, 179 KB

english, 2005

25

Mass Spectrometry-Based Quantification of CYP Enzymes to EstablishIn Vitro/In VivoScaling Factors for Intestinal and Hepatic Metabolism in Beagle Dog

Aki T. Heikkinen, Arno Friedlein, Jens Lamerz, Peter Jakob, Paul Cutler, Stephen Fowler, Tara Williamson, Roberto Tolando, Thierry Lave, Neil Parrott

Journal:

Pharmaceutical Research

Year:

2012

Language:

english

File:

PDF, 321 KB

english, 2012

26

Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea™

Neil Parrott, Thierry Lavé

Journal:

European Journal of Pharmaceutical Sciences

Year:

2002

Language:

english

File:

PDF, 637 KB

english, 2002

27

Islet cell transplantation: current status in the UK

Pratik Choudhary, Neil R Parrott, Linda Birtles, Martin K Rutter

Journal:

Practical Diabetes

Year:

2012

Language:

english

File:

PDF, 501 KB

english, 2012

28

Hypolipidaemic properties of a potent and bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor (RP 73163) in animals fed diets low in cholesterol

David Riddell, Colin P. Bright, Brenda J. Burton, Raymond C. Bush, Neil V. Harris, David Hele, Una M. Moore, Kuni Naik, David P. Parrott, Christopher Smith, Robert J. Williams

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.23 MB

english, 1996

29

Acyl-CoA:Cholesterol O -Acyltransferase (ACAT) Inhibitors. 2. 2-(1,3-Dioxan-2-yl)-4,5-diphenyl-1 H -imidazoles as Potent Inhibitors of ACAT

Astles, Peter C., Ashton, Michael J., Bridge, Andrew W., Harris, Neil V., Hart, Terrance W., Parrott, David P., Porter, Barry, Riddell, David, Smith, Christopher, Williams, Robert J.

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 568 KB

english, 1996

30

A Physiologically Based Pharmacokinetic Model of the Minipig: Data Compilation and Model Implementation

Claudia Suenderhauf, Neil Parrott

Journal:

Pharmaceutical Research

Year:

2013

Language:

english

File:

PDF, 455 KB

english, 2013

31

Predicting Pharmacokinetic Food Effects Using Biorelevant Solubility Media and Physiologically Based Modelling

Hannah M. Jones, Dr Neil Parrott, Gerd Ohlenbusch, Thierry Lavé

Journal:

Clinical Pharmacokinetics

Year:

2006

Language:

english

File:

PDF, 209 KB

english, 2006

32

Development of a Physiologically Based Model for Oseltamivir and Simulation of Pharmacokinetics in Neonates and Infants

Mr Neil Parrott, Brian Davies, Gerhard Hoffmann, Annette Koerner, Thierry Lave, Eric Prinssen, Elizabeth Theogaraj, Thomas Singer

Journal:

Clinical Pharmacokinetics

Year:

2011

Language:

english

File:

PDF, 218 KB

english, 2011

33

Physiologically Based Pharmacokinetic Modelling to Predict Single- and Multiple-Dose Human Pharmacokinetics of Bitopertin

Parrott, Neil, Hainzl, Dominik, Alberati, Daniela, Hofmann, Carsten, Robson, Richard, Boutouyrie, Bruno, Martin-Facklam, Meret

Journal:

Clinical Pharmacokinetics

Year:

2013

Language:

english

File:

PDF, 794 KB

english, 2013

34

In VitroandEx VivoInvestigation of the Impact of Luminal Lipid Phases on Passive Permeability of Lipophilic Small Molecules Using PAMPA

Markopoulos, Constantinos, Imanidis, Georgios, Vertzoni, Maria, Symillides, Mira, Parrott, Neil, Reppas, Christos

Journal:

Pharmaceutical Research

Year:

2013

Language:

english

File:

PDF, 272 KB

english, 2013

35

Dissolution media simulating the proximal canine gastrointestinal tract in the fasted state

Arndt, Marcel, Chokshi, Hitesh, Tang, Kin, Parrott, Neil J., Reppas, Christos, Dressman, Jennifer B.

Journal:

European Journal of Pharmaceutics and Biopharmaceutics

Year:

2013

Language:

english

File:

PDF, 525 KB

english, 2013

36

Use of physiologically based pharmacokinetic modeling for assessment of drug–drug interactions

Baneyx, Guillaume, Fukushima, Yumi, Parrott, Neil

Journal:

Future Medicinal Chemistry

Year:

2012

Language:

english

File:

PDF, 2.22 MB

english, 2012

37

Applications of a 7-day Caco-2 cell model in drug discovery and development

Peng, Ying, Yadava, Preeti, Heikkinen, Aki T., Parrott, Neil, Railkar, Aruna

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 1.18 MB

english, 2014

38

Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: Influence of time between substrate and inducer administration

Baneyx, Guillaume, Parrott, Neil, Meille, Christophe, Iliadis, Athanassios, Lavé, Thierry

Journal:

European Journal of Pharmaceutical Sciences

Year:

2014

Language:

english

File:

PDF, 2.28 MB

english, 2014

39

Pharmacokinetics of Paracetamol in Göttingen Minipigs:In VivoStudies and Modeling to Elucidate Physiological Determinants of Absorption

Suenderhauf, Claudia, Tuffin, Gerald, Lorentsen, Helle, Grimm, Hans-Peter, Flament, Christophe, Parrott, Neil

Journal:

Pharmaceutical Research

Year:

2014

Language:

english

File:

PDF, 705 KB

english, 2014

40

Physiologically Based Absorption Modelling to Predict the Impact of Drug Properties on Pharmacokinetics of Bitopertin

Parrott, Neil, Hainzl, Dominik, Scheubel, Emmanuel, Krimmer, Siegfried, Boetsch, Christophe, Guerini, Elena, Martin-Facklam, Meret

Journal:

The AAPS Journal

Year:

2014

Language:

english

File:

PDF, 964 KB

english, 2014

41

The role of quantitative ADME proteomics to support construction of physiologically based pharmacokinetic models for use in small molecule drug development

Heikkinen, Aki T., Lignet, Floriane, Cutler, Paul, Parrott, Neil

Journal:

PROTEOMICS - Clinical Applications

Year:

2015

Language:

english

File:

PDF, 971 KB

english, 2015

42

Evaluating a physiologically based pharmacokinetic model for prediction of omeprazole clearance and assessing ethnic sensitivity in CYP2C19 metabolic pathway

Feng, Sheng, Cleary, Yumi, Parrott, Neil, Hu, Pei, Weber, Cornelia, Wang, Yongqing, Yin, Ophelia Q. P., Shi, Jun

Journal:

European Journal of Clinical Pharmacology

Year:

2015

Language:

english

File:

PDF, 447 KB

english, 2015

43

Blood Pressure Success Zone: You Auto Know A Worksite-Based Program to Improve Blood Pressure Control Among Auto Workers

Jackson, James, Kohn–Parrott, Kate A., Parker, Cyndy, Levins, Neil, Dyer, Susan, Hedalen, Erika J., Frank, Elaine, Bramer, Susan, Brandt, Debra, Doyle, Joseph J.

Journal:

Population Health Management

Year:

2011

Language:

english

File:

PDF, 408 KB

english, 2011

44

Impact of 100% Fruit Juice Consumption on Diet and Weight Status of Children: An Evidence-based Review

Crowe-White, Kristi, O'Neil, Carol E., Parrott, J. Scott, Benson-Davies, Sue, Droke, Elizabeth, Gutschall, Melissa, Stote, Kim S., Wolfram, Taylor, Ziegler, Paula

Journal:

Critical Reviews in Food Science and Nutrition

Year:

2015

Language:

english

File:

PDF, 403 KB

english, 2015

45

Investigating the effect of autoinduction in cynomolgus monkeys of a novel anticancer MDM2 antagonist, idasanutlin, and relevance to humans

Glenn, Kelli J., Yu, Li J., Reddy, Micaela B., Fretland, Adrian J., Parrott, Neil, Hussain, Sazzad, Palacios, Mary, Vazvaei, Faye, Zhi, Jianguo, Tuerck, Dietrich

Journal:

Year:

2015

Language:

english

File:

PDF, 558 KB

english, 2015

46

Metabolic Impact of 100% Fruit Juice Consumption on Antioxidant/oxidant Status and Lipid Profiles of Adults: An Evidence-based Review

Crowe-White, Kristi, Parrott, J. Scott, Stote, Kim S., Gutschall, Melissa, Benson-Davies, Sue, Droke, Elizabeth, O'Neil, Carol E., Wolfram, Taylor, Ziegler, Paula

Journal:

Critical Reviews in Food Science and Nutrition

Year:

2015

Language:

english

File:

PDF, 718 KB

english, 2015

47

Using Physiologically Based Pharmacokinetic (PBPK) Modelling to Gain Insights into the Effect of Physiological Factors on Oral Absorption in Paediatric Populations

Villiger, Angela, Stillhart, Cordula, Parrott, Neil, Kuentz, Martin

Journal:

The AAPS Journal

Year:

2016

Language:

english

File:

PDF, 828 KB

english, 2016

48

Combining ‘Bottom-Up’ and ‘Top-Down’ Methods to Assess Ethnic Difference in Clearance: Bitopertin as an Example

Feng, Sheng, Shi, Jun, Parrott, Neil, Hu, Pei, Weber, Cornelia, Martin-Facklam, Meret, Saito, Tomohisa, Peck, Richard

Journal:

Clinical Pharmacokinetics

Year:

2016

Language:

english

File:

PDF, 1.59 MB

english, 2016

49

Simulation-Based Evaluation of PK/PD Indices for Meropenem Across Patient Groups and Experimental Designs

Kristoffersson, Anders N., David-Pierson, Pascale, Parrott, Neil J., Kuhlmann, Olaf, Lave, Thierry, Friberg, Lena E., Nielsen, Elisabet I.

Journal:

Pharmaceutical Research

Year:

2016

Language:

english

File:

PDF, 1.36 MB

english, 2016

50

Outcome of Pancreas Transplantation in Recipients Older Than 50 Years: A Single-Centre Experience

Ablorsu, Elijah, Ghazanfar, Abbas, Mehra, Sanjay, Campbell, Babatunde, Riad, Hany, Pararajasingam, Ravi, Parrott, Neil, Picton, Michael, Augustine, Titus, Tavakoli, Afshin

Journal:

Transplantation Journal

Year:

2008

Language:

english

File:

PDF, 213 KB

english, 2008